ONG NON-CODING RNA RP11-96L14.7 ALLEVIATES HEART FAILURE BY INCREASING HNRNPC-MEDIATED RYR2 MRNA STABILITY
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چکیده
منابع مشابه
Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release.
BACKGROUND Junctophilin-2 (JPH2) is the primary structural protein for the coupling of transverse (T)-tubule associated cardiac L-type Ca channels and type-2 ryanodine receptors on the sarcoplasmic reticulum within junctional membrane complexes (JMCs) in cardiomyocytes. Effective signaling between these channels ensures adequate Ca-induced Ca release required for normal cardiac contractility. D...
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As a critical step toward understanding the role of abnormal intracellular Ca(2+) release via the ryanodine receptor (RyR(2)) during the development of hypertension-induced cardiac hypertrophy and heart failure, this study examines two questions: 1) At what stage, if ever, in the development of hypertrophy and heart failure is RyR(2) hyperphosphorylated at Ser(2808)? 2) Does the spatial distrib...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2020
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(20)31321-8